TolC affects virulence gene expression in Vibrio cholerae.
نویسندگان
چکیده
A Vibrio cholerae tolC mutant showed increased toxT expression in M9 medium, but not in the presence of four amino acids that induce cholera toxin production, and in LB with high osmolarity but not high pH or temperature. TolC did not affect expression of other regulatory genes in the ToxR regulon.
منابع مشابه
Vibrio cholerae tolC is required for bile resistance and colonization.
TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization.
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عنوان ژورنال:
- Journal of bacteriology
دوره 193 20 شماره
صفحات -
تاریخ انتشار 2011